Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Procrastination is a chronic and widespread problem; however, emerging work raises questions regarding the strength of the relationship between self-reported procrastination and behavioral measures of task engagement. This study assessed the internal reliability, concurrent validity, predictive validity, and psychometric properties of 10 self-report procrastination assessments using responses collected from 242 students. Participants’ scores on each self-report instrument were compared to each other using correlations and cluster analysis. Lasso estimation was used to test the self-report scores’ ability to predict two behavioral (...) measures of delay. The self-report instruments exhibited strong internal reliability and moderate levels of concurrent validity. Some self-report measures were predictive of days to study completion. No self-report measures were predictive of deadline action pacing, the pacing style most commonly associated with procrastination. Many of the self-report measures of procrastination exhibited poor fit. These results suggest that researchers should exercise caution in selecting self-report measures and that further study is necessary to determine the factors that drive misalignment between self-reports and behavioral measures of delay. (shrink)

The Second Conference of the International Society for the Study of Time was held at Hotel Mt. Fuji, near Lake Yamanaka, Japan, on July I to 7,1973. The present volume is the proceedings at that Con ference and constitutes the second volume in The Study of Time series. * At the closing session of our First Conference in Oberwolfach, Germany, in 1969, I was honored by being elected to the Presidency of the Society, following Dr. J. G. Whitrow, our fIrst (...) President. My mandate was to organize a Second Conference, consistent with the aim of the Society, which is the holding of interdisciplinary conferences for the presentation and discussion of papers on various as pects of time. Several participants expressed to me their wish to have a second conference held in Japan so as to emphasize the international and intercultural dedication of this Society. Dr. Fraser carefully evaluated this and many other suggestions, weighed the possible conference sites and our chances of raising the necessary funds to convene a meeting at such sites, and concurred with my conclusions that we should go ahead with the plans for a Japanese meeting. For the difficult and complicated task of raising funds and organizing a conference in Japan, I had to select and rely heavily on somebody both capable and reliable and also living in Japan. Thus, I asked the Reverend Michael Mutsuo Yanase, S. J. (shrink)

Four studies measured or manipulated beliefs in free will to illuminate how such beliefs are linked to other aspects of personality. Study 1 showed that stronger belief in free will was correlated with more gratitude, greater life satisfaction, lower levels of perceived life stress, a greater sense of self-efficacy, greater perceived meaning in life, higher commitment in relationships, and more willingness to forgive relationship partners. Study 2 showed that the belief in free will was a stronger predictor of life satisfaction, (...) meaning in life, gratitude, and self-efficacy than either locus of control or implicit person theory. Study 3 showed that experimentally manipulating disbelief in free will caused a reduction in the perceived meaningfulness of life. Study 4 found that inducing a stronger belief in free will caused people to set more meaningful goals for themselves. The possible concern that believers in free will simply claim all manner of positive traits was contradicted by predicted null finding.. (shrink)

Do philosophic views affect job performance? The authors found that possessing a belief in free will predicted better career attitudes and actual job performance. The effect of free will beliefs on job performance indicators were over and above well-established predictors such as conscientiousness, locus of control, and Protestant work ethic. In Study 1, stronger belief in free will corresponded to more positive attitudes about expected career success. In Study 2, job performance was evaluated objectively and independently by a supervisor. Results (...) indicated that employees who espoused free will beliefs were given better work performance evaluations than those who disbelieve in free will, presumably because belief in free will facilitates exerting control over one’s actions. (shrink)

Even after yet another grand conjecture has been proved or refuted, any omniscience principle that had trivially settled this question is just as little acceptable as before. The significance of the constructive enterprise is therefore not affected by any gain of knowledge. In particular, there is no need to adapt weak counterexamples to mathematical progress.

LET ME BEGIN this inquiry with the simple but fundamental fact that the flow of time, or passage, as it is also known, is given in experience, that it is as indubitable an aspect of our perception of the world as the sights and sounds that come in upon us, even though it is not the peculiar property of a special sense. Consider, by way of illustration, that I am now sitting at the desk in my study. This particular event (...) was not present at any earlier time, nor will it be present shortly as I become involved in other activities. The present, as I experience it, is regularly associated with later and later events. It does not hop about capriciously from here to a later time, to a previous time, and then to a much later time, or trace out some other such indiscriminate pattern; instead I find it always in association with the next moment, and as I look backward and inward, so to speak, I find that the prior moment was present and that this next-later moment is present. Quite often this condition is expressed by means of imagery. We are asked to envision either a moving present racing along a fixed track of moments or events from earlier to later, or alternatively a fixed present through which stream a series of moments or events, first the earlier and then the later ones. One is in truth hard-pressed to find references to passage which do not employ quasi-poetical tropes and metaphors, and while these do help in some sense to say what we mean, great caution is required when handling them because of their ready tendency to draw us away from the actual phenomenon requiring explanation. (shrink)

Aworkshop was held August 26–28, 2015, by the Earth- Life Science Institute (ELSI) Origins Network (EON, see Appendix I) at the Tokyo Institute of Technology. This meeting gathered a diverse group of around 40 scholars researching the origins of life (OoL) from various perspectives with the intent to find common ground, identify key questions and investigations for progress, and guide EON by suggesting a roadmap of activities. Specific challenges that the attendees were encouraged to address included the following: What key (...) questions, ideas, and investigations should the OoL research community address in the near and long term? How can this community better organize itself and prioritize its efforts? What roles can particular subfields play, and what can ELSI and EON do to facilitate research progress? (See also Appendix II.) The present document is a product of that workshop; a white paper that serves as a record of the discussion that took place and a guide and stimulus to the solution of the most urgent and important issues in the study of the OoL. This paper is not intended to be comprehensive or a balanced representation of the opinions of the entire OoL research community. It is intended to present a number of important position statements that contain many aspirational goals and suggestions as to how progress can be made in understanding the OoL. The key role played in the field by current societies and recurring meetings over the past many decades is fully acknowledged, including the International Society for the Study of the Origin of Life (ISSOL) and its official journal Origins of Life and Evolution of Biospheres, as well as the International Society for Artificial Life (ISAL). (shrink)

We investigate how nonstandard reals can be established constructively as arbitrary infinite sequences of rationals, following the classical approach due to Schmieden and Laugwitz. In particular, a total standard part map into Richman's generalised Dedekind reals is constructed without countable choice.

Should weak forms of the axiom of choice really be accepted within constructive mathematics? A critical view of the Brouwer-Heyting-Kolmogorov interpretation, accompanied by the intention to include nondeterministic algorithms, leads us to subscribe to Richman's appeal for dropping countable choice. As an alternative interpretation of intuitionistic logic, we propose to renew dialogue semantics.

Objective: Even when critically ill patients are almost certain to die from their illnesses, there is generally an element of prognostic uncertainty. Little is known about how physicians handle this uncertainty in conversations with surrogate decision makers. We sought to evaluate whether and how physicians discuss prognostic uncertainty with surrogate decision makers of patients who are highly likely, but not certain, to die. Design: We audiotaped and transcribed discussions between clinicians and surrogate decision makers at two major California teaching hospitals (...) from 2006 through 2008. Physicians completed a questionnaire addressing their prognostic estimates for patients' survival to hospital discharge. Participants: We included physicians and surrogates of 12 incapacitated, critically ill patients. Measurements: We analyzed transcripts of discussions in which physicians' estimates of patients' chances of hospital survival were 1% to 5%; we coded whether physicians disclosed the prognostic uncertainty and, if so, how they conveyed that death was highly likely but not certain. Results: Physicians' estimates of short-term survival were 1% to 5% for 12 of the 70 patients enrolled in the original study. In 8 of 12 cases, physicians conveyed prognostic uncertainty by using probabilistic language or by an explicit mention of uncertainty. In four cases, physicians made at least one statement that either implied or was ambiguous about whether death was certain. Conclusion: We observed variability in how physicians handle prognostic uncertainty in their discussions with surrogates of patients who are highly likely, but not certain, to die, including some circumstances in which physicians stated or implied that death was certain. (shrink)

This chapter contains sections titled: Of Greek Gods, the Judaeo‐Christian God, and the Sea A Ship Bound for India Beyond the Pillars of Hercules.

The long-standing conflict between the two theories centers about the question whether time can exist independently of that which is in it. Those who advocate absolute time answer in the affirmative while the relationists take the opposite position claiming that temporal relations, and thus time, have no reality apart from the things and events which they order. In the terminology of Paul Weiss, relational time is "concrete." The considerable emphasis placed upon this issue of the concreteness of time has adversely (...) affected the absolute theory, leading to presentations of the absolutist position that are confusing, if not erroneous. Absolute time, as interpreted by philosophers such as Broad, Gunn, and Whitehead, posits the existence of abstract moments which are arranged in serial order one before the other by virtue of relations of precedence between them. Things and events participate in time only vicariously, so to speak, being joined to their respective moments by another kind of relation which Whitehead calls "occupation." The overall structure presented by the absolute theory is therefore thought to be as follows: one event is before another if both are respectively bound by relations of occupation to moments which are in turn so related as to be one before the other. Relational time mercifully simplifies this picture by a neat bit of surgery, cutting away the abstract moments and tying the relations of precedence directly to things and events themselves. As a consequence, the parasitic relations of occupation wither away. (shrink)

First it will be necessary to examine the argument, and the meaning of the argument, by which Mr. Ingram-Pearson is led to uphold such an unusual position. Using the statement, "fairies do not exist," as his example, he observes: "In order to achieve its obvious status as a denial this statement must have some object of reference for its subject term; for denials which are denials of nothing are not denials in any sense at all." What, then, is the designate (...) of the term "fairies"? It is, we are told, "an existent [italics mine] which at least one person believes to be present in the world and which another person at the same time and in the same context believes is not there." To say that "fairies do not exist" is therefore to say that "certain entities, designated by the term 'fairies,' are not present in the world," or "specific entities, designated by the term 'fairies,' are really absent from the world." The latter statement is positive, and Mr. Ingram-Pearson tells us explicitly that positive statements cannot "succeed in making intelligible" something made intelligible by negative statements about non-existents; but he has in mind such "ordinary" positive statements as "fairies are imagined beings." In other words, it is not that negative statements about. (shrink)

In this paper I shall examine creation and annihilation in time rather than solipsism of the moment. The argument will focus upon a difficulty raised by the creationist's qualification of the solipsist's denial of past and future. The solipsist maintains that the words "past" and "future" have no object of reference; hence, statements denying their existence, like such statements as "Fairies do not exist" and "Santa Claus does not exist," convey the idea that there simply are no existents to which (...) the subject terms refer. At no point can we accuse the solipsist of making the absurd claim that some existents do not exist, and yet that is precisely the claim which the creationist makes; for his subject term refers to some existent—something which does exist or did exist—and then he denies the existence of that existent. Indeed, he cannot express himself without granting existence, on the one hand, and denying it, on the other, so that he appears at the very outset to be involved in a contradiction. If the following argument is correct, it will prove that the contradiction is not merely apparent but real, and that the creationist is confronted by it as soon as he says what he wants to say in whatever idiom he chooses to say it. (shrink)

This book bridges the gaps between logic, mathematics and computer science by delving into the theory of well-quasi orders, also known as wqos. This highly active branch of combinatorics is deeply rooted in and between many fields of mathematics and logic, including proof theory, commutative algebra, braid groups, graph theory, analytic combinatorics, theory of relations, reverse mathematics and subrecursive hierarchies. As a unifying concept for slick finiteness or termination proofs, wqos have been rediscovered in diverse contexts, and proven to be (...) extremely useful in computer science. The book introduces readers to the many facets of, and recent developments in, wqos through chapters contributed by scholars from various fields. As such, it offers a valuable asset for logicians, mathematicians and computer scientists, as well as scholars and students. (shrink)

In this consensus report by a diverse group of academics who conduct and/or are concerned about social and behavioral genomics (SBG) research, the authors recount the often‐ugly history of scientific attempts to understand the genetic contributions to human behaviors and social outcomes. They then describe what the current science—including genomewide association studies and polygenic indexes—can and cannot tell us, as well as its risks and potential benefits. They conclude with a discussion of responsible behavior in the context of SBG research. (...) SBG research that compares individuals within a group according to a “sensitive” phenotype requires extra attention to responsible conduct and to responsible communication about the research and its findings. SBG research (1) on sensitive phenotypes that (2) compares two or more groups defined by (a) race, (b) ethnicity, or (c) genetic ancestry (where genetic ancestry could easily be misunderstood as race or ethnicity) requires a compelling justification to be conducted, funded, or published. All authors agree that this justification at least requires a convincing argument that a study's design could yield scientifically valid results; some authors would additionally require the study to have a socially favorable risk‐benefit profile. (shrink)

Objective: The establishment of patient-centered measures capable of empirically determining meaningful cognitive change after surgery can significantly improve the medical care of epilepsy patients. Thus, this study aimed to develop reliable change indices (RCIs) and standardized regression-based (SRB) change norms for a comprehensive neuropsychological test battery in the German language. Methods: Forty-seven consecutive patients with temporal lobe epilepsy underwent neuropsychological assessments, both before and 12 months after surgery. Practice-effect-adjusted RCIs and SRB change norms for each test score were computed. To (...) assess their usefulness, the presented methods were applied to a clinical sample, and binary logistic regression analyses were conducted to model the odds of achieving improvement in quality of life (QOL) after surgery. Results: The determined RCIs at 90% confidence intervals, and the SRB equations for each test score included in the test battery are provided. Cohen’s kappa analyses revealed a moderate mean agreement between the two measures, varying from slight to almost perfect agreement across test scores. Using these measures, a negative association between improvement in QOL and decline in verbal memory functions after surgery was detected. Significance: To the best of our knowledge, this study is the first to provide RCIs and SRB change norms necessary for the objective determination of neuropsychological change in a comprehensive test battery in the German language, facilitating the individual monitoring of improvement and decline in each patients’ cognitive functioning and psychosocial situations after epilepsy surgery. The application of the described measures revealed a strong negative association between improvement in QOL and decline in verbal memory functions after surgery. (shrink)

Identifying the determinants of reproductive success in small-scale societies is critical for understanding how natural selection has shaped human evolution and behavior. The available evidence suggests that status-accruing behaviors such as hunting and prosociality are pathways to reproductive success, but social egalitarianism may diminish this pathway. Here we introduce a mixed longitudinal/cross-sectional dataset based on 45 years of research with the Batek, a population of egalitarian rain forest hunter-gatherers in Peninsular Malaysia, and use it to test the effects of four (...) predictors of lifetime reproductive success: foraging return rate, sharing proclivity, cooperative foraging tendency, and kin presence. We found that none of these factors can explain variation in lifetime reproduction among males or females. We suggest that social egalitarianism, combined with strikingly low infant and juvenile mortality rates, can mediate the pathway between foraging, status-accruing behavior, and reproductive success. Our approach advocates for greater theoretical and empirical attention to quantitative social network measures, female foraging, and fitness outcomes. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Being-Moved: Rhetoric as the Art of Listening by Daniel M. GrossNathaniel A. RiversBeing-Moved: Rhetoric as the Art of Listening. By Daniel M. Gross. Oakland: University of California Press, 2020. 260 pp. Paper $34.95. ISBN: 9780520340466.September 29, 2008. Radiohead front man Thom Yorke sits frustrated at his piano. Live on stage. He is trying to start a song, but something is tripping him up. The song is “Videotape,” and (...) he cannot start playing it. “Temporary loss of information,” he mumbles to an expectant crowd.The song “Videotape” is syncopated, meaning there is a “placement of rhythmic stresses or accents where they wouldn’t normally occur” (Wikipedia 2021). Practically, it means that Yorke is joining a song already in progress: there is a beat before the beat that “starts” the song. Yorke, then, is starting the song not on the down beat but after the down beat—after the song has already started. He needs to hear something before he can play anything. He needs to hear the beat before he can sing. “Give me the fuckin’ hi-hats only,” he asks.Yorke is moved by the drum and a beat not his alone. It is a beat preceding him to which he must become subject. He needs to listen, but it is a particular kind of listening: a passive listening that makes him, as it were, “subject to the instruction of others” (Gross 137).Like Yorke on stage in 2008, I struggled to start and write this review. Not for any fault in the book, which is clear and concise, complex and compelling, but because I wanted to write a review that practiced the art of listening Gross cultivates:Active listening [“auditor-as-judge”], as it is understood by theoreticians and practitioners of persuasion from classical antiquity through today, only takes off at dusk like Hegel’s owl of Minerva, leaving behind obscurities of our daily lives including our susceptibility [End Page 190] to advertising, our political apathy, our immersion in common-sense, our lovely credulity, our vulnerability to others, our very capacity to learn and change. We have much work ahead when it comes to the theoretical and practical nuances of listening in its passive dimensions.(137)This review practices listening to this call in this way. The worry remains that the genre of the book review tends toward what Gross identifies as active listening: the judge, the critic. I should probably be the “active listener-as-judge” (83). Surely, a good reviewer should protect future readers from a “bad teacher” (131). But how should a book review practicing passive listening read? Does it aim for learning? Surely. Credulity? Why not. Subjection? Hmm.... It is, after all, subjection that lies at the heart of Gross’s book. Subjection is the beat before the beat that is rhetoric, an art forever syncopated.There are many aspects of Gross’s argument, which I will hear out below, but key for me, and crucial for Gross’s argument, is his emphasis on passive dispositions (e.g., apathy, adherence, suggestibility, attentiveness, etc.) crucial to political formations and so vital to rhetoric. Being moved, toward which rhetoric (sacred rhetoric especially) bends, must admit not only to the prowess and power of the rhetor but also, necessarily, to the “basic vulnerability that lies at the heart of political agency itself ” (1). Indeed, “Rhetoric as a life science depends upon those lives affected” (8). Because of this dependence (and dependencies saturate the arts of listening), “rhetoric offers much more detail because it is the traditional domain where subjection is both theorized and practiced” (3).To articulate this offer, Gross works through what he describes as the “orphaned materials of modernity [that] often turn out to be vital strains of a different geology altogether” (12). Gross is here describing his own historiographic methodology. There are other things to hear in and about rhetoric. The core of his argument isn’t simply that listening is a practice important to rhetoric, with listening understood as a kind of critical facility—what Gross calls “active listener-as-judge” (83–84). Listening, for Gross, through his approach to Heidegger, bears upon being and becoming... (shrink)

W. V. Quine famously argues that though all knowledge is empirical, mathematics is entrenched relative to physics and the special sciences. Further, entrenchment accounts for the necessity of mathematics relative to these other disciplines. Michael Friedman challenges Quine’s view by appealing to historicism, the thesis that the nature of science is illuminated by taking into account its historical development. Friedman argues on historicist grounds that mathematical claims serve as principles constitutive of languages within which empirical claims in physics and the (...) special sciences can be formulated and tested, where these mathematical claims are themselves not empirical but conventional. For Friedman, their conventional, constitutive status accounts for the necessity of mathematics relative to these other disciplines. Here I evaluate Friedman’s challenge to Quine and Quine’s likely response. I then show that though we have reason to find Friedman’s challenge successful, his positive project requires further development before we can endorse it. (shrink)

In June 2017, President Trump announced that the US intends to withdraw from the Paris Agreement. The decision was widely viewed as an abrogation of US leadership in confronting a changing climate. I’m not interested here in the decision to withdraw from Paris per se. Instead, I’m interested in Paris as a useful contrast for the administration’s attitude towards a different international environmental agreement: the Montreal Protocol.

In a fragment entitled Elementa Nova Matheseos Universalis Leibniz writes “the mathesis [...] shall deliver the method through which things that are conceivable can be exactly determined”; in another fragment he takes the mathesis to be “the science of all things that are conceivable.” Leibniz considers all mathematical disciplines as branches of the mathesis and conceives the mathesis as a general science of forms applicable not only to magnitudes but to every object that exists in our imagination, i.e. that is (...) possible at least in principle. As a general science of forms the mathesis investigates possible relations between “arbitrary objects”. It is an abstract theory of combinations and relations among objects whatsoever. In 1810 the mathematician and philosopher Bernard Bolzano published a booklet entitled Contributions to a Better-Grounded Presentation of Mathematics. There is, according to him, a certain objective connection among the truths that are germane to a certain homogeneous field of objects: some truths are the “reasons” of others, and the latter are “consequences” of the former. The reason-consequence relation seems to be the counterpart of causality at the level of a relation between true propositions. Arigorous proof is characterized in this context as a proof that shows the reason of the proposition that is to be proven. Requirements imposed on rigorous proofs seem to anticipate normalization results in current proof theory. The contributors of Mathesis Universalis, Computability and Proof, leading experts in the fields of computer science, mathematics, logic and philosophy, show the evolution of these and related ideas exploring topics in proof theory, computability theory, intuitionistic logic, constructivism and reverse mathematics, delving deeply into a contextual examination of the relationship between mathematical rigor and demands for simplification. (shrink)